RAS Protein Flexibility & How to Target Cryptic Pockets to Drug the Undruggable Master Oncogene

Time: 12:00 pm
day: Day One


• RAS is a very flexible protein without any apparent druggable pocket which has resisted three decades of efforts to drug it

• Cryptic or induced pockets can be identified in addition to so-called SII pocket

• DNA-encoded library approach is a powerful approach to drug cryptic pockets such as SII pocket